Clinical Neuroscience

[ Parkinsonism bromocriptine (Parlodel) 5-year experience of treatment ]

LIPCSEY Attila1, PERES Aladár1, RÉVÉSZ Tamás2

MAY 01, 1985

Clinical Neuroscience - 1985;38(05)

[The authors have been conducting systematic trials of Parlodel (bromocriptine) in combination treatment of patients with Parkinson's disease for 5 years.Parlodel has been used in 56 patients. Their patient population includes a significant number of elderly patients and patients tolerated Parlodel better than any other antiparkinsonian drug. No significant side effects were observed. In complex treatment, the use of Parlodel has been shown to reduce the dose of other antiparkinsonian drugs (including L-dopa) in some cases. It was found to be effective in patients with on-off, wearing-off phenomena in therapy-resistant cases. ]

AFFILIATIONS

  1. Fővárosi János Kórház-Rendelőintézet, Neuropsychiatriai Osztály
  2. Fővárosi János Kórház-rendelőintézet, Neuropsychiatriai Osztály

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[The Hourglass Model of Psychiatric Diseases, illustrated by the example of endogenous psychoses]

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[Taking Jaspers' concept as a starting point, the author has previously proposed an orientation along the conceptual continuum of disease entities. Along this conceptual continuum of disease, which is not a continuum between disease and normality, the psychopathological syndrome is defined as a disease with a defined duration (small disease unit) or a psychopathological syndrome with a defined duration (small disease unit). The variables of the disease process indicating psychopathological and social adaptation disorders are empirically shown to form a relatively antagonistic open system. Based on this finding and using the concepts of multiaxial classifications, the author has developed the so-called hourglass model as an extension of the linear model of illness, which reflects the interweaving of life history and pathology, and allows the development of testable hypotheses and the synthesis of a biological and a social psychiatric approach. ]

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[Migraine with atypical and persistent symptoms]

MOLNÁR Erzsébet, GÁCS Gyula

[The authors analyze data on complicated migraine patients treated for headaches in an inpatient unit. They highlight the relative prevalence, variations, and differential diagnostic problems of the pathology. One of their cases of complicated migraine attacks developed posterior cerebral artery occlusion with permanent visual field loss. They emphasize the importance of cases of "migraine without a headache" with persistent symptoms in approaching the pathomechanism of the pathology from a clinical point of view. ]

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[Treatment of Parkinson's disease in Bács-Kiskun county]

MATEJKA Zsuzsanna

[The communication describes the number of Parkinson's disease patients registered in Bács-Kiskun County and the use of drugs in the treatment of the disease. The author concludes that due to the disastrously low number of neuro-mental beds and the lack of specialists, the reassuring screening, care, and drug therapy of the disease in the county are not solved. ]

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[Report]

KÉKESI Ferenc

[Report of the Synapse-50 conference, held to celebrate the 50th anniversary of the Montreal Neurological Institute and Hospital, 23-26 September 1984 in Montreal. ]

Clinical Neuroscience

[Report of the SM conference held by the Department of Neurology of the Polish Academy of Sciences on 14 and 15 June 1984 in Lodz]

PÁLFFY György

[During the two-day session, national and international experts reported on their research in the biochemical histochemistry, immunology, clinical and epidemiology of multiple sclerosis.]

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We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

Clinical Neuroscience

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Clinical Neuroscience

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