Clinical Neuroscience

[Guillain-Barré syndrome gallbladder carcinoma]

SZŐKE Tamás1, HAFFNER Zsolt1, KOMÁR József1

NOVEMBER 01, 1963

Clinical Neuroscience - 1963;16(11)

[The authors describe a case of gallbladder carcinoma with an initial clinical presentation of Guillain-Barré syndrome, the underlying disease only becoming clear at autopsy. They add to the evidence for the effect of metastases in causing polyneuropathy. They support a polyaetiological view of the pathomechanism of carcinomatous polyneuropathy. Guillain-Barré syndrome caused by gallbladder carcinoma has not been found in the literature, as Dodgson and Hoffmann reported only polyneuropathy caused by bronchus carcinoma, except in an esophageal carcinoma. ]


  1. Fővárosi István Kórház Idegosztálya



Further articles in this publication

Clinical Neuroscience

[Data on intracranial space narrowing in the elderly diagnosis and differential diagnosis of intracranial intracranial processes]

GÁTAI György

[1. Intracranial space-occupying processes in the elderly differ from the average in both localization and specificity in younger age. The difference is so pronounced that diagnostic conclusions can be drawn on the basis of age as to the location and nature of the process. 2. Multiple tumours are much more common in older age. This fact should be taken into account in the diagnosis of multiple nodal syndromes in old age. 3. Solitary intracranial space-occupying processes in elderly patients are mainly supratentorial. If extraparenchymal, they are mostly not true tumours, are benign and can be successfully treated by surgery; if intraparenchymal, they are predominantly deep-seated, malignant tumours that cannot be surgically manipulated. An exception to the latter are spontaneous intra cerebral haematomas. 4. Axial constrictive processes, especially in the brainstem and cerebellum, are very rare in older age. Such localisations are probably not due to a single tumour. 5. Infratentorial space-occluding processes are significantly less frequent than the average, primarily primary (non-metastatic) small tumours. The majority of infratentorial tumours are pontocerebellar, benign. 6. Intracranial space-occluding processes in the elderly are polarising in terms of specificity: in addition to malignant, incurable tumours, vascular space-occluding processes of surgical origin are becoming more frequent, while the more "benign" tumours, which account for the majority of younger cases, are becoming rare. 7. The vast majority (4/5) of brain tumours with symptomatic onset over 60 years are malignant. Involutional age predisposes to malignant brain tumour development; benign tumours detected in old age usually start to develop before rather than at involutional age. ]

Clinical Neuroscience

[Experience of Frenolone-Melipramine Combination Treatment in Chronic Schizophrenics ]


[It can be concluded that our trials with Frenolone + Melipramine combination have shown positive results both in terms of beneficial effects on pathological symptoms and insignificant side effects. Although we cannot draw any firm conclusions due to the small number of cases, we consider that further studies are warranted on the basis of appropriate indications. ]

Clinical Neuroscience

[Some aspects of psychotherapy for alcoholists]


[The authors aim to contribute to the efforts of the new phase in the fight against alcoholism in the country by drawing on a decade of experience. In grouping their patient material, they identify the development of an awareness of the disease as a primary task, which also determines the direction of psychotherapy. They see the more effective work of the social services as a prerequisite for the content of medical intervention, the avoidance of false results and, last but not least, the elimination of factors that prevent regression, through appropriate preparation. They touch on the link between alcoholism and psychopathy, and attribute the causes of alcoholism, particularly in rural areas, to the underlying motives behind unmet needs. In addition to awakening an awareness of the disease, which is a genuine voluntary activity, the creation of more optimal cultural opportunities is also seen as a key task, in order to develop a greater sense of community. In the case of those subject to enforced withdrawal, it would be preferable to establish appropriate work camps under medical supervision, rather than a purely medical form of treatment. Measures to eradicate alcoholism can only be effective if medical and social action are more closely linked.]

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Cases of inborn errors of metabolism diagnosed in children with autism

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Autism spectrum disorder is a neurodevelopmental disorder with a heterogeneous presentation, the etiology of which is not clearly elucidated. In recent years, comorbidity has become more evident with the increase in the frequency of autism and diagnostic possibilities of inborn errors of metabolism. One hundred and seventy-nine patients with diagnosis of autism spectrum disorder who presented to the Pediatric Metabolism outpatient clinic between 01/September/2018-29/February/2020 constituted the study population. The personal information, routine and specific metabolic tests of the patients were analyzed retrospectively. Out of the 3261 patients who presented to our outpatient clinic, 179 (5.48%) were diagnosed with autism spectrum disorder and were included in the study. As a result of specific metabolic examinations performed, 6 (3.3%) patients were diagnosed with inborn errors of metabolism. Two of our patients were diagnosed with classical phenylketonuria, two with classical homocystinuria, one with mucopolysaccharidosis type 3D (Sanfilippo syndrome) and one with 3-methylchrotonyl Co-A carboxylase deficiency. Inborn errors of metabolism may rarely present with autism spectrum disorder symptoms. Careful evaluation of the history, physical examination and additional findings in patients diagnosed with autism spectrum disorder will guide the clinician in the decision-making process and chose the appropriate specific metabolic investigation. An underlying inborn errors of metabolism may be a treatable cause of autism.

Clinical Neuroscience

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Clinical Neuroscience

A variant of Guillain-Barre syndrome after SARS-CoV-2 vaccination: AMSAN

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Introduction - Coronavirus disease 2019 (COVID-19) is a respiratory infection that has rapidly become a global pandemic and vaccines against SARS-CoV-2 have been developed with great success. In this article, we would like to present a patient who developed Guillain-Barré syndrome (GBS), which is a serious complication after receiving the inactive SARS-CoV-2 vaccine (CoronaVac). Case report – A 76-year-old male patient presented to the emergency department with nine days of progressive limb weakness. Two weeks prior to admission, he received the second dose of CoronaVac vaccine. Motor examination revealed decreased extremity strength with 3/5 in the lower extremities versus 4/5 in the upper extremities. Deep tendon reflexes were absent in all four extremities. Nerve conduction studies showed predominantly reduced amplitude in both motor and sensory nerves, consistent with AMSAN (acute motor and sensory axonal neuropathy). Conclusion - Clinicians should be aware of the neuro­logical complications or other side effects associated with COVID-19 vaccination so that early treatment can be an option.

Clinical Neuroscience

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Clinical Neuroscience

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