Clinical Neuroscience

[Glioma behaviour in tissue culture III. Comparative study of in vivo irradiated gliomas ]

ZOLTÁN László1, PÁLYI Irén1, ÁFRA Dénes1

JULY 01, 1963

Clinical Neuroscience - 1963;16(07)

[1. We performed a comparative study of four gliomas after first and recurrent surgery. Simultaneous tissue culture of the surgical material was performed. 2. Two patients operated on with glioblastoma multiforme and one with astrocytoma malignum received radiotherapy after the first surgery, whereas one patient operated on with astrocytoma malignum did not receive radiotherapy. 3. Irradiation resulted in a reduction in the ability of tumour cells to grow for longer periods of time in tissue culture, which was already reflected in the degeneration that occurred. The decrease in biological activity of irradiated tumour cells can be considered as a consequence of the radiation effect. 4. In one case, a malignant lesion was observed in non-irradiated tumour tissue after histological processing during recurrent surgery. 5. In one case, the activity of the tumour tissue removed at the first surgery showed a malignant astrocytoma in culture, which predicted a malignant lesion in the tissue removed at the second surgery. ]

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  1. Országos Idegsebészeti Tudományos Intézet, Budapesti Orvostudományi Egyetem Szövet- és Fejlődéstani Intézet

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Clinical Neuroscience

[Clinical group psychotherapy for neurotics]

HIDAS György

[Group psychotherapy uses a whole with new characteristics, created by the human social relationships and mutual interaction between the patients and the psychotherapist doctor, to heal. The conscious behaviour and psychotherapeutic work of the doctor play a crucial role. Psychotherapeutic groups for neurotic patients in hospital are open, heterogeneous, with 6-8 members Group psychotherapy is not only a therapeutic method but also a diagnostic one, and the development of interpersonal relationships is observed in statu nascendi. The structure of a psychotherapeutic group in a hospital setting is determined by the neurotic tendency factor and the need for addiction. This creates a formation centred around the group leader. A crucial stage of therapy is the transformation of the group structure into a group-centred group. This requires and brings with it the patients' sense of autonomy, active work and a greater sense of responsibility. A psychotherapy group is also a "working group", which works on solving the problems that arise in order to achieve recovery. There is a conflict between the working group and the need for addiction, with the psychotherapeutic doctor as the dynamic point of conflict. The doctor's task is to create a tolerant atmosphere in the group, to establish the modus operandi and to keep the group psychotherapy process moving with his interpretations. An optimal degree of negative or positive emotional tension is required in group psychotherapy. One source of negative tension is the conflict between the patient's need to receive and the doctor's refusal to do so. Therapeutic factors in group psychotherapy are: positive emotions between the doctor and the patient, universalisation, catharsis, reflective reactions, interpretations, intellectual and emotional insight, self-awareness and enrichment of knowledge, counselling, group reality testing. In the course of group psychotherapy, healthy, self-healing forces are mobilised, healthy adaptability increases, a sense of community is extended, and feelings of isolation are reduced. The doctor is involved in the group psychotherapy process in an emotional way. This is necessary in order to help patients adequately, but his perception may be disturbed by his emotions. The participation of an observing physician in a group psychotherapy session is a support and learning experience for the therapist. The results of group psychotherapy are: patients get to know each other better, the patient-physician relationship becomes more intense. The psychotherapeutic atmosphere of the ward is improved by channeling the patients' conflicts with the hospital and with each other. The patients' sense of community is strengthened and their interpersonal relationships improve. There is an opportunity to change the neurotic way of coping. The spontaneous interaction of patients, which often leads to negative effects, is used for healing in hospital through conscious intervention and guidance in group psychotherapy. ]

Clinical Neuroscience

[Data on temporal lobe symptomatology Pick's atrophy ]

BALAJTHY Béla

[Three cases of Pick's atrophy in which atrophy spread from the primary shrinkage center in temporopolar to T, T, and Tz are described. Individual differences in the further pathway of atrophy were discernible: in case 1, it extended only to the frontal basis, in case 2, it extended additionally to F, and in case 3, it extended, albeit to a small extent, to the whole frontal convexity. In the first two cases, the atrophy was more pronounced on the left side, in the third on the right. The symptoms were partly the same in all three cases according to the common pathological lesions and partly variable from case to case according to the specific pathological lesions and the predominance of laterality. Common symptoms included initial mnestic disruption and subsequent severe dementia associated with bilateral temporal lobe atrophy and personality changes upon spread to the frontal base. Aphasic symptoms are modified not only by the predominance of the lesion on the lesion side, but also by the frontal spread. The aphasia in the period of temporal atrophy is transcortical motor typus; this was accompanied by echolalia in case 2 when the frontal supplementary motor regio was impaired. The "oral tendencies" and hypersexuality in our case 3 are similar to Klüver-Bucy syndrome and are probably related to particularly severe bilateral temporal atrophy.]

Clinical Neuroscience

[The "benign" form of multiple sclerosis]

LEHOCZKY Tibor, HALASY Margit

[62 patients with multiple sclerosis are reported to be in the "benign" group of the disease. Cases of each of the three subgroups are described. Methods (palliative care, rehabilitation plan, etc.) are discussed to hope for a favourable outcome: stabilisation of the disease, making it stationary. The need to set up convalescent resorts and rehabilitation centres is stressed. Examples of the former are TB sanatoria and the latter poliomyelitis outpatient clinics.]

Clinical Neuroscience

[Minutes of the meeting]

ÁDÁM György, KUKORELLI Tibor, ÁNGYÁN L.G.T. Sakhiulina, GRASTYÁN E., KLINBERG F. , KARMOS G., CZOPF J., ENDRŐCZI E., LISSÁK K., HARTMAN G., NIKOLITS Ilona, KERTAI Pál, DÉSI Illés, CZABALAI László, MAGYAR István, ASZALÓS Zoltán, OBÁL F., MADARÁSZ I., ZOLTÁN Ö. T., FÖLDI M., FEHÉR Ottó, MECHLER Ferenc, HALÁSZ Péter, KAJTOR F., ÓVÁRY I., ZSADÁNYI O., KASZÁS T., NAGY Tibor, BOHÁR Anna, WALSA Róbert, RÁBAI Kálmán, HASZNOS T. , FENYŐ E., ANTAL J., TOMKA Imre, REMENÁR László, FORNADI F., FRATER R., SZEGEDI L., SZENDE Otto, NEMESSURI Mihály, FÉNYES István, BÖTSKEY O., KRECSÁNYI J.

[The VI. scientific meeting of the Hungarian EEG Society was held in Budapest on 8-9 February 1963. of the VI. meeting of the EEG.]

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Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study

NÉMETH Klára Zsófia, SZÛCS Anna , VITRAI József , JUHÁSZ Dóra , NÉMETH Pál János , HOLLÓ András

We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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Cases of inborn errors of metabolism diagnosed in children with autism

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Clinical Neuroscience

Late simultaneous carcinomatous meningitis, temporal bone infiltrating macro-metastasis and disseminated multi-organ micro-metastases presenting with mono-symptomatic vertigo – a clinico-pathological case reporT

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Clinical Neuroscience

Alexithymia is associated with cognitive impairment in patients with Parkinson’s disease

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Clinical Neuroscience

[The role of sleep in the relational memory processes ]

CSÁBI Eszter, ZÁMBÓ Ágnes, PROKECZ Lídia

[A growing body of evidence suggests that sleep plays an essential role in the consolidation of different memory systems, but less is known about the beneficial effect of sleep on relational memory processes and the recognition of emotional facial expressions, however, it is a fundamental cognitive skill in human everyday life. Thus, the study aims to investigate the effect of timing of learning and the role of sleep in relational memory processes. 84 young adults (average age: 22.36 (SD: 3.22), 21 male/63 female) participated in our study, divided into two groups: evening group and morning group indicating the time of learning. We used the face-name task to measure relational memory and facial expression recognition. There were two sessions for both groups: the immediate testing phase and the delayed retesting phase, separated by 24 hours. 84 young adults (average age: 22.36 (SD: 3.22), 21 male/63 female) participated in our study, divided into two groups: evening group and morning group indicating the time of learning. We used the face-name task to measure relational memory and facial expression recognition. There were two sessions for both groups: the immediate testing phase and the delayed retesting phase, separated by 24 hours. Our results suggest that the timing of learning and sleep plays an important role in the stabilizing process of memory representation to resist against forgetting.]