Clinical Neuroscience

[Data for the differential diagnosis of acute nodal circulatory disorders of the brain ]

PÁLFFY György1

SEPTEMBER 01, 1965

Clinical Neuroscience - 1965;18(09)

[The author reviewed the clinical data of 222 patients with nodal cerebral circulatory disorders who underwent 2 sections and 2 surgeries. The percentage of complaints, symptoms and laboratory findings in the different cerebral circulatory disorders and the analysis of the sectional findings are used to draw conclusions about the possibility of a distinct pathophysiology of these diseases. ]

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  1. Somogy megyei Tanács Kaposvári Kórháza Ideg- és Elmeosztály

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Clinical Neuroscience

[Our CSF cytodiagnostic experience]

PÉTER Ágnes

[Our cerebrospinal fluid cytology tests were a definite diagnostic aid in our leukemic patient only. Bischoff points out that the meningogram can also be specific for tumour metastasis, retotheliosis, subarachnoid haemorrhage and parasites. In our cases, we could not draw a sharp line between granulomatous and inflammatory lesions. In our patients with bacterial and bacterial meningitis, we found significant differences in the involvement of granulocytes and plasma cells, with some morphological regularities depending on the aetiology. In some viral-derived inflammatory neuropathies, we observed strikingly intense plasmocytic reactions, concomitant with young immature cell forms that could not be classified into Bischoff cytological reactotypes. He considered the plasmocytic reaction to being characteristic of chronic granulomatous images. Wieczorek raised the question of a functional relationship between phages and reticulum cells on the basis of their coincidence. We would raise the question of a functional relationship between plasma cells and reticulum cells for the same reason, which we believe is evidenced by the occurrence of plasma cellular reticulum cells (a. 6). In some cases in the literature, we have analyzed for the first time the cerebrospinal fluid cytology of patients with panencephalitis.]

Clinical Neuroscience

[Fahr's atherosclerosis of the brain ]

SZOKOLY Viktor, ZSADÁNYI Ottó

[The clinical signs and pathological findings of intracerebral, non-atherosclerotic, idiopathic diffuse atherosclerosis are described. The course of the disease and the putative pathomechanisms are discussed. ]

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We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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Cases of inborn errors of metabolism diagnosed in children with autism

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Clinical Neuroscience

Late simultaneous carcinomatous meningitis, temporal bone infiltrating macro-metastasis and disseminated multi-organ micro-metastases presenting with mono-symptomatic vertigo – a clinico-pathological case reporT

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Clinical Neuroscience

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Clinical Neuroscience

Cholinesterase inhibitors and memantine for the treatment of Alzheimer and non-Alzheimer dementias

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In aging societies, the morbidity and mortality of dementia is increasing at a significant rate, thereby imposing burden on healthcare, economy and the society as well. Patients’ and caregivers’ quality of life and life expectancy are greatly determined by the early diagnosis and the initiation of available symptomatic treatments. Cholinesterase inhibitors and memantine have been the cornerstones of Alzheimer’s therapy for approximately two decades and over the years, more and more experience has been gained on their use in non-Alzheimer’s dementias too. The aim of our work was to provide a comprehensive summary about the use of cholinesterase inhibitors and memantine for the treatment of Alzheimer’s and non-Alzheimers’s dementias.