Clinical Neuroscience

[Comparative histopathological study of polyneuritis of different aetiology]


DECEMBER 31, 1954

Clinical Neuroscience - 1954;7(06)

[1. the author reviewed 14 cases of poly-neuritis of different aetiology and searched for a correlation between the quality and localisation of histological lesions and the aetiological factor. 2 Histopathological examination of all sections of the surrounding nervous system except terminal neuropathways was performed from three main aspects: a) quality of histological lesion - inflammation or degeneration, b) localization of the pathological process, c) axonal lesion and axonal retrograde cell changes. 3. 7 cases showed severe degeneration of the parenchyma of the surrounding nervous system with axonal cell changes. The site of the degeneration was the peripheral nerve (distal typus degeneration). In these cases, arsenic, achylia gastrica, hypovitaminosis, anaemia were aetiological factors. 4. 6 cases had generalized serous inflammation of the peripheral nervous system in the foreground of the histological picture, associated with degeneration of the medullary sheath and axodilatation without retrograde cellular changes. In contrast to the previous group, the degeneration was most severe in the dural sheath and in the root (proximal tympanic degeneration). The author, in agreement with Scheinker and Sántha, seeks an explanation for the proxymal radicular marrow degeneration in that the swollen root is strangulated in the dural sheath. In these cases, an allergic reaction (after influenza, pneumonia, tonsillitis, ulcus molle, gastritis) is postulated as the aetiological factor. The last case corresponds to polyganglinitis, in which a viral origin is likely. 5. Histopathological examination of the cases shows that the aetiological factors which primarily cause the metabolic abnormalities of the nervous system are those which cause a distal-type parenchymal degenerative process of the surrounding nervous system. As a consequence of an allergic reaction or infection, a radicular interstitial inflammatory process develops. 6 To distinguish between these two processes, the author, following Lewy and Wechsler, considers it appropriate to call the first group of cases 'polyneuropathy' and the latter 'polyganglioradiculitis' (as explained in the text), on the basis of the localisation of the degenerative lesions.]


  1. Debreceni Orvostudományi Egyetem Ideg- és Elmeklinikája



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[Central nervous system and RES. I. Nervous system regulation of liver RES]

CSABA György, RAPPAY György

[Our experiments were carried out on 80 healthy white rats, males and females. The aim of our experiments was to determine the neuromuscular influence and regulation of reticuloendathelium. The experimental methodology used was the stabilized Törő-Velősy procedure. By surgically and pharmacologically performing the experiments with subcortical agents, we found that: 1. RES (hepatic RES) is under the regulation of the central nervous system. 2. Sympathetic excitation increases and parasympathetic excitation decreases RES activity.]

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[Multinucleated sympathetic ganglion cell in humans]


[In view of the foregoing, it must therefore be concluded, contrary to previous observations, that the formula in the cervical sympathetic ganglia of healthy adult humans, also in the ggl. c. sup., can be regarded as an abnormal element and its formation is presumably due to a cell division disorder.]

Clinical Neuroscience

[Lectures and presentations of scientific meetings]

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