Clinical Neuroscience

[Changes in protein fractions in blood after partial removal of the cerebral cortex and lesion of certain areas of the central nervous system (hypothalmus, formatio reticularis)]

MAROS Tibor1, KOVÁCS Endre1, MÓDY Jenő1, LÁZÁR László1

OCTOBER 01, 1959

Clinical Neuroscience - 1959;12(10)

[The authors have observed how damage to different parts of the central nervous system causes changes in the protein fractions in the blood. Their experimental studies in 57 dogs show that partial removal of the cerebral cortex produces only temporary changes in this respect. These transient changes are not specific but are rather a consequence of the general trauma associated with surgery. Injury to the hypothalamus results in permanent shifts in alpha and beta globulins, while electrical disruption of the formatio reticularis adjacent to the raphe mesencephali produces absolute and relative decreases in albumin and significant increases in alpha 2 and gamma globulin fractions. The authors conclude that there are centres and pathways in the hypothalamus and along the brainstem formatio reticularis that control protein metabolism, the closer delineation of which requires further research. ]

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  1. Román Népköztársaság Akadémiája Marosvásárhelyi Kutatóállomása Idegszövettani Laboratóriuma és Biokémiai Laboratóriuma

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[On the basis of 15 clinically and pathologically reviewed cases, the author considers that there is no firm basis for distinguishing between Dawson's inclussios, Pette-Döring's pan-, and van Bogaert's subacute sclerotoid leukoencephalitis and therefore proposes the name subacute progressive panencephalitis. The disease (group) has a wide spectrum of pathological variation and is not considered to be a direct consequence of the underlying inflammatory process, but a product of complicating anoxic-vascular disorders. By presenting 3 cases, he demonstrates anoxic-vascular effects ranging from a few days of cortical erythema and transudative damage to several years to months of ulegyria. With respect to the formal genesis of anoxia-vascular injury, he considers the complex interplay of cardiac, circulatory, respiratory, and local intracranial cavity vascular tamponade, which may be compounded by cytotoxic effects due to liver dysfunction.]

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[Right complete hemihypertrophy with schizophrenia associated with schizophrenia]

ADORJÁNI Ferenc, BŐHM Tivadar

[Hemihypertrophy (hh.) is the enlargement of one half of the body relative to the other half. In complete hh., this enlargement extends from the skull to the toes and includes bones and soft tissues. The first clinical study of hh. was published by Wagner (37) in 1839, followed by Friedberg (6) in 1867 who described crossed hypertrophy (h.). Gesell (9, 10) reviewed the literature of cases published up to that time in 1921 and 1927, followed by Lenstrup (20), Wakefield and Hines (38), Petre (26), Schwartzmann and colleagues (36), E. Toussaint Aragon (1), Sayer and Fatherre (32), Rugel (29), Ward and Lerner (39) described their patients. According to Sylver and Gruskay (34), no fewer than 130 cases were reported in the literature up to 1957. ]

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[The role of cash benefits for people with mental illness therapeutic employment of mental mental patients]

TÖRÖK István, LESCH Gyula

[It is a long-established fact that reasonable employment is beneficial for the mentally ill. Institutions with a long tradition, such as the Soviet institutions or the Polish Berenice, the East German Goerden, the West German Gütersloh and Lengerich, the Czechoslovak institutions and many others, have developed therapeutic occupations and systems based on experience. Here, unfortunately, therapeutic employment is still in its infancy. But it would also be of benefit to the national economy. ]

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[The author reviews Klinische Psychotherapie innerer Krankheiten.]

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Fluoxetine use is associated with improved survival of patients with COVID-19 pneumonia: A retrospective case-control study

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We aimed to investigate the association between fluoxetine use and the survival of hospitalised coronavirus disease (COVID-19) pneumonia patients. This retrospective case-control study used data extracted from the medical records of adult patients hospitalised with moderate or severe COVID-19 pneumonia at the Uzsoki Teaching Hospital of the Semmelweis University in Budapest, Hungary between 17 March and 22 April 2021. As a part of standard medical treatment, patients received anti-COVID-19 therapies as favipiravir, remdesivir, baricitinib or a combination of these drugs; and 110 of them received 20 mg fluoxetine capsules once daily as an adjuvant medication. Multivariable logistic regression was used to evaluate the association between fluoxetine use and mortality. For excluding a fluoxetine-selection bias potentially influencing our results, we compared baseline prognostic markers in the two groups treated versus not treated with fluoxetine. Out of the 269 participants, 205 (76.2%) survived and 64 (23.8%) died between days 2 and 28 after hospitalisation. Greater age (OR [95% CI] 1.08 [1.05–1.11], p<0.001), radiographic severity based on chest X-ray (OR [95% CI] 2.03 [1.27–3.25], p=0.003) and higher score of shortened National Early Warning Score (sNEWS) (OR [95% CI] 1.20 [1.01-1.43], p=0.04) were associated with higher mortality. Fluoxetine use was associated with an important (70%) decrease of mortality (OR [95% CI] 0.33 [0.16–0.68], p=0.002) compared to the non-fluoxetine group. Age, gender, LDH, CRP, and D-dimer levels, sNEWS, Chest X-ray score did not show statistical difference between the fluoxetine and non-fluoxetine groups supporting the reliability of our finding. Provisional to confirmation in randomised controlled studies, fluoxetine may be a potent treatment increasing the survival for COVID-19 pneumonia.

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Clinical Neuroscience

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Clinical Neuroscience

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Clinical Neuroscience

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