Clinical Neuroscience

Burning mouth syndrome: Evaluation of clinical and laboratory findings

HALAC Gulistan1, TEKTURK Pinar2, EROGLU Saliha3, CIKRIKCIOGLU Ali Mehmet4, CIMENDUR Ozlem5, KILIC Elif6, ASIL Talip1

JULY 30, 2016

Clinical Neuroscience - 2016;69(07-08)


Background and purpose - Burning mouth syndrome is a chronic and persistent painful condition characterized by burning sensation in the oral mucosa. We investigated the etiological factors of patients presented with the history of burning in the mouth who admitted our outpatient clinics over the 8-years period and who had no underlying identifiable local factors. We also tried to determine their demographic and clinical characteristics. Our aim was to investigate the association between burning mouth and psychiatric disorders such as depression and anxiety, chronic diseases like diabetes mellitus (DM) and other laboratory studies in patients complaining of solely burning in the mouth. Methods - The study included patients with the history of burning in mouth who presented in our outpatient clinic between 2005 and 2012. They were evaluated by a neurologist, a psychiatrist, an internist, and a dentist. Complete blood counts, biochemical analysis and cranial magnetic resonance imaging (MRI) were performed for all patients. Results - A total of 26 (22 (84%) females, 4 (15%) males; mean age 55.9 years) patients were enrolled in this study. Five (19.2%) of the patients had depression, 2 (7.7%) had anxiety disorder, 2 (7.7%) had diabetes mellitus, 8 (30%) had B12 vitamin deficiency, 3 (11.5%) had decreased ferritin levels in blood, and 1 (3.8%) had folic acid deficiency. Cranial MRI of all patients were normal. Nine patients (34.6%) had no etiological causes. Conclusion - A multidisciplinary approach in the management of burning mouth and establishment of common criteria for the diagnosis would provide insight into the underlying pathophysiological mechanism.


  1. Bezmialem Vakıf University, Faculty of Medicine, Department of Neurology, Istanbul, Turkey
  2. Istanbul University, Istanbul Medical Faculty, Department of Neurology, Istanbul, Turkey
  3. Bezmialem Vakıf University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Istanbul, Turkey
  4. Bezmialem Vakıf University, Faculty of Medicine, Department of Internal Medicine, Istanbul, Turkey
  5. Bezmialem Vakıf University, Faculty of Dentistry, Department of Prosthodontics, Istanbul, Turkey
  6. Bezmialem Vakıf University, Faculty of Medicine, Department of, Deparment Of Medical Biochemistry, Istanbul, Turkey



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