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Clinical Neuroscience - 2014;67(03-04)
Content
Clinical Neuroscience
MARCH 30, 2014
Clinical Neuroscience
MARCH 30, 2014
Clinical Neuroscience
MARCH 30, 2014
Clinical Neuroscience
MARCH 30, 2014
[HANS SELYE 70 YEARS LATER: STEROIDS, STRESS ULCERS & H. PYLORI]
[Although Hans Selye is mostly known for his discovery & development of the stress concept, he also introduced the first physiologically sound, structure-activity classification of steroids that was also based on the chemical structure of steroids in 1943. He not only introduced the names of glucocorticoids & mineralocorticoids but discovered the anti- & pro-inflammatory properties, respectively, of these steroids in animal models. Furthermore, he not only described the first stress-induced... tovább »
Clinical Neuroscience
MARCH 30, 2014
[CATECHOLAMINES AND STRESS]
[A brief survey is offering of debates on two long-standing questions in stress studies and theories: 1) question of stress nonspecificity (i.e. homo- or heterogeneity in stress responses), and 2) what is the functional role of central catecholamines in stress mechanisms, especially in stress signaltransduction and in the realization of stress responses.]
Clinical Neuroscience
MARCH 30, 2014
[HANS SELYE AND THE STRESS RESPONSE: FROM “THE FIRST MEDIATOR” TO THE IDENTIFICATION OF THE HYPOTHALAMIC CORTICOTROPIN-RELEASING FACTOR]
[Selye pioneered the stress concept that is ingrained in the vocabulary of daily life. This was originally build on experimental observations that divers noxious agents can trigger a similar triad of endocrine (adrenal enlargement), immune (involution of thymus) and gut (gastric erosion formation) responses as reported in a letter to Nature in 1936. Subsequently, he articulated the underlying mechanisms and hypothesized the existence of a “first mediator” in the hypothalamus able to orchestrate... tovább »
Clinical Neuroscience
MARCH 30, 2014
[THE SURPRISING DUAL ACTION OF GLUCOCORTICOIDS]
[Glucocorticoid hormones may have dual action on the stomach: physiological gastroprotective and pathological proulcerogenic one. In physiological conditions, even in acute stress situations, glucocorticoids have an adaptive effect on the stomach and, therefore, are gastroprotective. The findings that we review in this article suggest that glucocorticoids released during acute stress are naturally occurring protective factors that play an important role in maintenance of the gastric mucosal... tovább »
Clinical Neuroscience
MARCH 30, 2014
Clinical Neuroscience
MARCH 30, 2014
[SELYE’S CONCEPT OF PLURICAUSAL DISEASES AND ITS IMPACT ON REGULATORY SCIENCE]
[Science assumed in recent decades an increasingly important role in the regulatory field. Regulatory science is now regarded as established specific brunch of science. A disturbing anomaly, the emergence of fraudulent data is of major concern both in the field of research and in the regulation. Hans Selye’s work on stress, on several forms of pluricausal diseases and on other experimental models came into the focus of interest on the occasion of the Selye Symposium - 2013 held in May 2013 at... tovább »
Clinical Neuroscience
MARCH 30, 2014
[STRESS IN THE CLASSIFICATION OF PITUITARY TUMORS. FOCUS ON AGGRESSIVE PITUITARY ADENOMAS]
[After a brief summary of the stress concept and the contribution of Dr. Hans Selye, this publication focuses on the classification of pituitary neoplasms and the difficulties to provide conclusive information on the prognosis of various pituitary tumor types. The term “aggressive pituitary tumors” was introduced. These tumors have a rapid cell proliferation rate. At present, the assessment of Ki-67 nuclear labeling index appears to be the simplest and most reliable method to evaluate tumor... tovább »
Clinical Neuroscience
MARCH 30, 2014
[CENTRAL NEUROENDOCRINE MECHANISMS OF GASTROPROTECTION]
[Selye recognized the importance of activation of hypothalamic- pituitary-adrenal axis during stress and the connection between central nervous system and neuroendocrine regulation. This concept basically contributed to initiation of the studies, which revealed the importance of brain gut axis in regulation of gastric mucosal integrity. Several neuropeptides, such as thyreotrop releasing hormones, adrenomedullin, peptide YY, amylin, opioid peptides, nociceptin, nocisatin, substance P, ghrelin,... tovább »
Clinical Neuroscience
MARCH 30, 2014
[EVEN VISITING SCIENTISTS COULD MAKE DISCOVERIES IN MONTREAL]
[This publication summarizes the scientific adventure with Professor Selye, and focuses on the specific effect of rare metal salts on reticuloendothelial functions. Rare earth metal ions markedly affect the functions of cells involved in inflammatory and immunological phenomena. The Kupffer cell blockade induced by GdCl3 is a generally accepted method for investigation of the physiological and pathophysiological roles of Kupffer cells. Potential beneficial effects of macrophage blockade have... tovább »
Clinical Neuroscience
MARCH 30, 2014
[A PSYCHIATRIST’S PERSPECTIVES ON STRESS, STEROIDS AND MENTAL ILLNESS]
[The relationship between stress and mental illness has been extensively studied and there is a growing consensus that the occurrence of mental illness rather depends on a combination of factors than is caused by stressful external events. Significant hypothalamus pituitary adrenal axis abnormalities were observed among others in major depressive disorder and bipolar disorder. In both disorders, the extent of change in cortisol level was related to the severity of illness and to cognitive... tovább »
Clinical Neuroscience
MARCH 30, 2014
[HANS SELYE: AN INSPIRING TEACHER]
[The souvenirs of Hans Selye as a teacher of graduate and post graduate students are presented and discussed. The main aim of his teaching was to orient the student toward importance and originality of findings.]
Clinical Neuroscience
MARCH 30, 2014
[PERSONAL RECOLLECTIONS OF DR. HANS SELYE AND OF HIS INSTITUT DE MÈDECINE ET DE CHIRURGIE EXPÈRIMENTALES (IMCE)]
[This article is a short personal recollection of Dr. Hans Selye (HS) and of his institute in order to show, first, why and how he influenced us; second, who he was as a person, human being, physician, scientist, professor, mentor; third, what was the structure and functioning of the Institut de mèdecine et chirurgie expèrimentales (IMCE) and fourth, what HS’ contributions and accomplishments were.]
Clinical Neuroscience
MARCH 30, 2014
[Validation of the Hungarian MDS-UPDRS: Why do we need a new Parkinson scale?]
[Background - The Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) has been published in 2008 as the successor of the original UPDRS. The MDS-UPDRS organizing team developed guidelines for the development of official non- English translations consisting of four steps: translation/back-translation, cognitive pretesting, large field testing, and clinimetric analysis. The aim of this paper was to introduce the new MDS-UPDRS and its validation... tovább »
Clinical Neuroscience
MARCH 30, 2014
[Association of temporal lobe inflammatory leukoencephalopathy with two B cell malignancies]
[Identification of etiological connections among virtually distinct diseases in a patient may be sometimes challenging. We report a unique case with two B cell malignancies and an inflammatory leukoencephalopathy. Three days prior to admission, the elderly male patient developed fatigue, headaches, recurrent vomiting, memory disturbances, depression and somnolence. Clinical, laboratory and imaging evaluations as well as post mortem histological studies were performed. Simultaneous presence of... tovább »
Clinical Neuroscience
MARCH 30, 2014
[Dilemma of further therapeutic step in RRMS in case of ineffectivity of first line treatment: fingolimod or natalizumab?]
[Dilemma of further therapeutic step in RRMS in case of ineffectivity of first line treatment: fingolimod or natalizumab? 2014;67(03-04)]
Clinical Neuroscience
MARCH 30, 2014
Clinical Neuroscience
MARCH 30, 2014
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