Clinical Neuroscience - 2011;64(09-10)

Clinical Neuroscience

SEPTEMBER 23, 2011

[Functional magnetic resonance imaging for cortical mapping in epilepsy]

KOZÁK Lajos Rudolf, TÓTH Vivien, BARSI Péter, RUDAS Gábor

[It is not only the total curative resection of pathological tissue or the minimization of symptoms to be considered in epilepsy surgery or other neurosurgical procedures, it is equally desirable to maintain the best possible quality of life. Cortical mapping methods can help achieve this goal by delineating eloquent areas, i.e. brain regions that are vital for providing an acceptable quality of life, albeit not prone to compensatory reorganization. These areas include among others the Broca... tovább »

Clinical Neuroscience

SEPTEMBER 23, 2011

[Magnetic resonance measuring and analitic methods in epilepsy]

BARSI Péter

[Neuroradiology and magnetic resonance imaging (MRI) as its leading tool play a basic role in the diagnostics of epilepsy. The result of the MRI examination is of utmost importance in patients with therapy resistent focal epilepsy possibly requiring neurosurgical intervention. Based on the continuously developing MRI techniques, we can use an optimal imaging protocol. Cerebral structures can be evaluated on a microanatomical level on high-resolution images with thin slices. The... tovább »

Clinical Neuroscience

SEPTEMBER 23, 2011

[LORETA (Low Resolution Electromagnetic Tomography): A three-dimensional EEG source localization method]

CLEMENS Béla

[The author presents a brief overview of the EEG source localization method LORETA (Low Resolution Electromagnetic Tomography) with special reference to the not widely discussed data.]

Clinical Neuroscience

SEPTEMBER 23, 2011

[The methodology and objectives of registrating high frequency oscillation in epilepsy]

CLEMENS Zsófia

[Technological advances in digital EEG allowed the recording the full frequency band of the EEG. Activity beyond the traditional 0.3-70 Hz band reflects both physiological and pathological processes. High frequency activity recorded from the epileptic brain has been related to both epileptogenicity and epileptogenesis. The article reviews research avenues, clinical applications, and the methodology of detecting and quantifying high frequency activity.]

Clinical Neuroscience

SEPTEMBER 23, 2011

[Prolonged EEG-monitoring]

HALÁSZ Péter

[Prolonged EEG monitoring and video-EEG monitoring are basic methods on the level of epilepsy centers. These methods are able to make differences between epilepsy and non epileptic paroxysmal manifestations like psychogenic non epileptic seizures, parasomniac phenomena, narcolepsy. The application of the method, at least the video-EEG variant, needs team work, high level organisation, highly educated staff and high tech electrographic devices. Running the method even with these requirements is... tovább »

Clinical Neuroscience

SEPTEMBER 23, 2011

[Role of deep brain stimulation in epilepsy]

JANSZKY József, BALÁS István, KOVÁCS Norbert

[The deep brain stimulation (DBS) is an emerging treatment option in brain disorders in which randomized multicenter trials proved its efficacy leading to licensing different DBS methods in various brain diseases. More recently more and more brain structures have become candidates for being “target” in a possible DBS treatment of epilepsy. At present, only the DBS of the anterior nucleus of the thalamus (ANT) can be considered as a proved method for epilepsy treatment. Other potential targets... tovább »

Clinical Neuroscience

SEPTEMBER 23, 2011

[The clinical utility of genetic testing in epilepsy]

KELEMEN Anna, GÁL Anikó

[We summarize those epilepsies, in which genetic testing has clinical significance. Different types of genetic tests are presented. Na-channel epilepsies include different clinical entities, the exact genetic diagnosis is relevant in the prognosis, genetic counseling, as well in the therapeutic decision - as Na-channel blockers may worsen them. Molecular genetic tests are available for most of the malformations of cortical development, important for genetic counseling and prenatal diagnosis.... tovább »

Clinical Neuroscience

SEPTEMBER 23, 2011

[Critical analysis of types and objectives of phamacological trials]

JUHOS Vera

[Antiepileptic drug randomized controlled trial (RCT) design has been criticized in the near past. Designs emphasize conventions and regulations more than clinical aspects. In the new study that scrutinized RCT patient recruitment has also raised important ethical issues. The time has come when changes in RCT design seem imperative.]

Clinical Neuroscience

SEPTEMBER 23, 2011

[New antiepileptic drugs, and therapeutic considerations]

SZUPERA Zoltán

[Epilepsy is not a singular disease, but a variety of disorders. It is affects up to 0.5% of the population. Over the past decade, the researchers have been made great advances in the field of epilepsy. These have been accompanied by the licensing of a great number of antiepileptic drugs. However, despite these efforts, up to 15-20% of patients have refractory epilepsy. The novel antiepileptic drugs must suit several requirements: higher efficacy, especially in resistant cases, better... tovább »

Clinical Neuroscience

SEPTEMBER 23, 2011

[The role of neuronavigation in the preoperative invasive evaluation and surgical treatment of drug resistant epilepsies]

ERÕSS Loránd

[For localizing the epileptogenic zone in cases of focal epilepsies detailed clinical investigations, imaging studies and electrophysiological methods are in use. In lesional epilepsies the intrapreoperatíve localization of the lesion and it’s location to the eloquent cortex is essential for the neurosurgeon. The development in image guided neurosurgery lead us to use neuronavigation systems to localize intracerebral lesions or functionally eloquent cortical areas or subcortical pathways during... tovább »

Clinical Neuroscience

SEPTEMBER 23, 2011

[Neuropsychological methods and trends in epilepsy management]

BORBÉLY Csaba

[Neuropsychological assessment makes its own valuable contribution to diagnosis in epilepsy, and the integration of those findings with the data from multiple sources provides the most comprehensive picture for a given epilepsy patient. The objective of this paper is to define and summarize the role and methods of neuropsychological assessment, and to present recommendations on themes for future clinical research in the neuropsychology of epilepsy.]

Clinical Neuroscience

SEPTEMBER 23, 2011

[Oligoepilepsy: a real entity or the benign form of epileptic disorder?]

RAJNA Péter, SÓLYOM András

[Background and purpose - Although oligoepilepsy (OLE) is a used term in many protocols, guidelines and the everyday routine, it is found practically nowhere in the scientific literature. The aim of our study is to investigate and evaluate of the main characteristics of his subcategory of epilepsy. We try to find answer to the basic question of not only theoretical but also great practical importance whether the OLE does really exist, is it an independent entity of epilepsy or only its general... tovább »

Clinical Neuroscience

SEPTEMBER 23, 2011