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[Chlamydia pneumoniae has recently been implicated in the pathogenesis of several neurological diseases. As an intracellular parasite with its unusual life cycle it is able to circumvent the immune system and to persist in the organism. It has the ability to modify the function of the infected cell and supposedly induce autoimmune reactions. These properties can make it pathogenic in several chronic neurological diseases including multiple sclerosis, atherosclerosis, stroke, Alzheimer dementia and giant cell arteriitis. The evaluation of the available, often contradictory, data that are based on various different methods is not easy. The importance of the issue is enhanced by the potential need for antibiotic treatment.]
[The notion of consciousness in the English scientific literature denotes a global ability to consciously perform elementary and intellectual tasks, to reason, plan, judge and retrieve information as well as the awareness of these functions belonging to the self, that is, being self-aware. consciouness can also be defined as continuous awareness of the external and internal environment, of the past and the present. The meaning of consciouness is different in various languages, but it invariably includes, the conscious person is capable to learn, retrieve and use information. Disturbance or loss of consciouness in the Hungarian medical language indicates decreased alertness or arousability rather than the impairment of the complex mental ability. Awareness denotes the spiritual process of perception and analysis of stimuli from the inner and external world. Alertness is a prerequisite of awareness. Clinical observations suggest that the lesions of specific structures of the brain may lead to specific malfunction of consciouness, therefore, consciouness must be the product of neural activity. “Higher functions” of human mental ability have been ascribed to the prefrontal and parietal association cortices. The paleocerebrum, limbic system and their connections have been considered to be the center of emotions, feelings, attention, motivation and autonomic functions. Recent evidence indicates that these phylogenetically ancient structures play an important role in the processes of acquiring, storing and retrieving information. The hippocampus has a key role in regulating memory, learning, emotion and motivation. Impaired consciouness in the neurological practice is classified based on tests for conscious behavior and by analyzing the following responses: 1. elementary reactions to sensory stimuli - these are impaired in hypnoid unconsciousness, 2. intellectual reactions to cognitive stimuli - these indicate the impairment of cognitive contents in nonhypnoid unconsciousness. Obviously, disturbance of elementary reactions related to alertness and disturbance of intellectual performance overlap. In conditions with reduced ability to react to or to perceive external stimuli the cognitive disturbance of consciouness cannot fully be explored.]
[Here we report on the development of an integrated general model for the control of limb movements. The model computes muscle forces and joint rotations as functions of activation signals from motoneuron pools. It models the relationship between neural signals, muscle forces and movement kinematics by taking into account how the discharge rates of motoneuron pools and the biomechanical characteristics of the musculoskeletal system affect the movement pattern that is produced. The lengths and inertial properties of limb segments, muscle attachment sites, the muscles’ force-length, force-frequency and force-velocity (of contraction) relationships, as well as a load parameter that simulates the effect of body weight are considered. There are a large number of possible ways to generate a planned joint rotation with muscle activation. We approach this “overcompleteness problem” by considering each joint to be controlled by a single flexor/extensor muscle pair and that only one of the two muscles is activated at a given time. Using this assumption, we have developed an inverse model that provides discharge rates of motoneuron pools that can produce an intended angular change in each joint. We studied the sensitivity of this inverse model to the muscle force-length relationship and to limb posture. The model could compute possible firing rates of motoneuron pools that would produce joint angle changes observed in rats during walking. It could also compare motoneuron activity patterns received for two different hypothetical force-length relations and show how the motoneuron pool activity would change if joints would be more flexed or extended during the entire movement.]
[Objective - Tremor is the most common movement disorder which is most often either essential or caused by Parkinson’s disease. The differentiation of these disorders at the initial stage may be difficult. Objective assessment of the efficacy of tremor medications is only possible by instrumental measurements. The aim of this study was to determine whether the computer assisted tremor analysis system CATSYS 2000 can help in the differentiation of parkinsonian from essential tremor. Methods - The rhythmicity and maximal frequency of fast alternating hand and finger movements, simple reaction time and postural instability were recorded in healthy controls (n=18), patients with Parkinson’s disease (n=39) and essential tremor (n=37). Data were digitally converted and statistically analyzed. Results - Tremor intensity, median frequency and frequency distribution showed characteristic differences in the three groups. Performance in fast alternating movements of hands and fingers were significantly worse in both tremor groups compared to the healthy controls. Conclusions - The data also indicated that quantitative measurements of tremor parameters must be performed on both sides, because the presence of significant side differences support the diagnosis of Parkinson’s disease. The method presented can be used to objectively analyze tremor and performance in rhythmic movements. The results show that it helps to differentiate parkinsonian from essential tremor as well as to predict disease course and the effectiveness of therapy. Multivariate statistical analysis of tremor and movement performance also provides an opportunity to study the pathogenesis of human tremor.]
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Clinical Neuroscience
[Headache registry in Szeged: Experiences regarding to migraine patients]2.
Clinical Neuroscience
[The new target population of stroke awareness campaign: Kindergarten students ]3.
Clinical Neuroscience
Is there any difference in mortality rates of atrial fibrillation detected before or after ischemic stroke?4.
Clinical Neuroscience
Factors influencing the level of stigma in Parkinson’s disease in western Turkey5.
Clinical Neuroscience
[The effects of demographic and clinical factors on the severity of poststroke aphasia]